Company profile: Evotec

Evotec

Evotec is a life science company with a unique business model that delivers on its mission to discover and develop highly effective therapeutics and make them available to the patients. The Company’s multimodality platform comprises a unique combination of innovative technologies, data and science for the discovery, development, and production of first-in-class and best-in-class pharmaceutical products. Evotec leverages this “Data-driven R&D Autobahn to Cures” for proprietary projects and within a network of partners including all Top 20 Pharma and over 800 biotechnology companies, academic institutions, as well as other healthcare stakeholders. Evotec has strategic activities in a broad range of currently underserved therapeutic areas, including e.g. neurology, oncology, as well as metabolic and infectious diseases. Within these areas of expertise, Evotec aims to create the world-leading co-owned pipeline for innovative therapeutics and has to-date established a portfolio of more than 200 proprietary and co-owned R&D projects from early discovery to clinical development. Evotec operates globally with more than 4,200 highly qualified people. The Company’s 15 sites offer highly synergistic technologies and services and operate as complementary clusters of excellence. For additional information please go to www.evotec.com and follow us on Twitter @Evotec and LinkedIn.

Categories

Late-Stage Clinical and Commercial cGMP Manufacturing Facility Tour | J.POD | Just-Evotec Biologics

Presentation details in full

Meet the Team

Dr Frédéric Somny
VP Business Development

Paul Wiedenau
Manager, API Chemistry

Eric Cogo
VP, DMPK and Developability Assessment

Matteo Daldosso
Manager, Physical Properties & Preformulation

Poster: Evotec CMC | Comprehensive, integrated capabilities and expertise

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Abstract

Evotec integrated approach to product development and delivery

Evotec's truly integrated capabilities fully support drug substance and drug product development and GMP manufacturing from FIH to Phase III clinical development programmes

Keywords: CMC; Chemistry Manufacturing & Controls; Drug Substance; Drug Product; GMP Manufacturing; API; Pre-formulation; Formulation development; Analytical Development; Material Science; Stability Testing; API polymorph screening, salt-selection, co-crystals screening; API route scouting, process development and scale-up; API GMP manufacturing; Solid state characterisation; Drug product formulation prototyping and development; Drug product process optimisation; scale-up; transfer to GMP production; Clinical manufacturing; Commercial manufacturing small volume/niche product; quality control; Project management; Quality Assurance; consultancy
Category: CMC: Small Molecule, Drug Product

Poster: Fast track formulation: A data driven approach for bioavailability challenging compounds

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Abstract

Solubility and permeability are two critical factors affecting the rate and extent of absorption of drug candidates entering the development pipeline. This can pose a significant challenge, as poor bioavailability is a common cause of attrition in drug development.

Keywords: SolubilitY; permeability; absorption; poor bioavailability; drug development; BCS class II, III and IV compounds; in vitro screening; in vivo screening; formulation; product design
Category: CMC: Small Molecule, Drug Product

Poster: Nanotechnology platform for the development of a broad range of nanomaterials

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Abstract

Nanotechnologies have a significant impact on the quality of life of millions of patients since the introduction of the first commercial products in the ‘90ies

Increasingly important approach to improve safety and efficacy profile of challenging molecules:
- To target drug specifically to the site of action
- To overcome low aqueous solubility and poor bioavailability

Evotec and leon-nanodrugs specialists can support the development of nanomaterials-based drug product from the preliminary screening and set-up of the nanosizing process to the downstream processing to finished dosage form.

Case study presented in the poster

Keywords: nanotechnology; nanomaterial; nanomaterials-based drug product; nanosizing process; downstream processing; finished dosage form; small molecule; large molecule; biologics; genetic materials; jet-impinging reactor; size-particle distribution; drug-delivery applications
Category: CMC: Biologics, Drug Product

Poster: J.DESIGN A data driven fully integrated technology platform for biotherapeutic development & manufacturing

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Abstract

Speed, capacity, quality, and the cost of biologics discovery, development and manufacturing are significant challenges for drug developers of all sizes and consequently create economic barriers for patients globally who need access to these important therapeutics.

Learn more about Just - Evotec Biologics J.DESIGN platform

Keywords: Biologics discovery; biologics development; biologics manufacturing; biotherapeutics; artificial intelligence; machine learning; J.DESIGN; AI-driven molecule discovery; molecule design; manufacturing design; process and product design; antibody sequence optimization;
Category: CMC: Biologics, Drug Substance

Resources

Evotec Company presentation

Just - Evotec Biologics | Introducing a paradigm shift in biologics

With Just –Evotec Biologics, Evotec aims to shift, together with our partners, the current paradigm for biologics discovery and manufacturing. Together we will create a massive impact by providing access to critical biotherapeutics.

Drug Product

End-to-End shared R&D | Integrated business-to-business platform for increased probability of success from target to the clinic

The flexibly accessible shared economy for successful R&D

Discovery Biology