Adam Patterson is an experienced research scientist with a demonstrated history of working in the pharmaceutical industry. Since joining Veranova in July 2016, Adam has both undertaken and led projects applying his expertise in solid state science to numerous active pharmaceutical ingredients. His work at Veranova covers polymorph screening, salt and cocrystal selection and crystallization development. Adam leads Veranova’s efforts in Raman spectroscopy with expertise in Raman mapping of drug products and also applies his skillset to the single crystal X-ray diffraction group, focusing on the structure solution of different solid forms of active pharmaceutical ingredients. Adam gained his PhD in Inorganic Chemistry from Trinity College Dublin, Ireland and an MChem from Durham University.

Presentation Title: A Novel Series of Ivosidenib-Polymer Cocrystals

Abstract: Novel series of Ivosidenib-Polymer cocrystals - Oral presentation by Adam R. Patterson, Veranova (Cambridge, UK)
Pharmaceutical salts are a ubiquitous front-line approach to improve the inherent low aqueous solubility of increasingly complex small molecules where an ionisable group is present. Within pharmaceuticals, cocrystals have been increasingly investigated and found wider regulatory acceptance in the prior two decades and their formation can provide a viable alternative to improve aqueous solubility and tune solid form properties of non-ionisable active molecules. We argue that cocrystallisation utilising polymers (common drug product excipients) instead of traditional small molecule coformers can generate cocrystals with a unique opportunity that can combine aspects of the drug substance and formulation development workflows of a drug product.
We present the case of a commercial molecule, Ivosidenib, a complex chiral drug substance used in the treatment of relapsed or refractory acute myeloid leukemia (R/R AML). The solid form landscape is complex with multiple hydrates, solvates and anhydrates. Of these, a series of alcohols forming
isostructural solvates was identified. The instability of these solvates makes developabilitychallenging and we have studied the substitution of the solvent for less labile entities such as polyethylene glycol (PEG) in the system.
We present the single crystal structures and complete solid-state characterisation of a series of Ivosidenib-PEG cocrystals to understand the interaction within the lattice. Whereas linear polymers have been crystallised with simple model systems (carbamazepine 1 , diflunisal 2 ), our work
demonstrates a solution crystallisation preparation at scale on a more complex molecule such as Ivosidenib. We suggest that small molecules forming a high number of solvates could be good candidates to evaluate for potential cocrystallisation with polymer materials.

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