Ruth completed her PhD at the University of Bath as part of CMAC where she worked on the preferential crystallization of metastable forms using both batch and continuous crystallization techniques. Since joining Veranova in 2019, Ruth has become a key member of the crystallization development team, working on a range of crystallization projects and aiding the continual development of this offering.

Presentation Title: From Vials to Vessels: Discovery and Development in the Salt / Cocrystal Continuum - Demonstrating Process Control at Scale Incorporating Particle Engineering Strategies

Abstract: The number of Active Pharmaceutical Ingredients (API) and Agrochemicals with sub-optimal physiochemical properties, such as poor solubility, dissolution and physical / chemical stability has increased over the last decade as active compounds generally have become complex. The solid form strongly influences these properties, and it is vitally important to understand and manufacture the appropriate solid form. Salts and cocrystals have been identified as viable solid forms that may improve the aforementioned properties of development candidates.
This talk will explore the crystallization of the Agrochemical Active Ingredient, Pyrimethanil (a broad-spectrum fungicide), which forms a wide variety of multi-component systems. Crystallization control is crucial for obtaining the desired solid form with the targeted particle properties. We will discuss the discovery of these forms through comprehensive screening and the subsequent investigation of solubility to guide crystallization development. By careful tuning of procedure parameters, the salt and cocrystal forms can be selectively isolated in pure phases by understanding the crystallization kinetics of each system. Finally, we will delve into the scale up of these moieties using particle engineering controls to achieve desired crystallization outcomes.

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